Elizabeth Mary Orgill (nee Gladstone) operated Gladstone House until at least 1911, along with another hydropathic hospital (Birthwood) on Cheltenham road. She was the daughter of William Gladstone (Nephew of William Ewart Gladstone, UK prime minister in 1874).
Around 1912 Dr A. E. Taylor took over the location from Dr. Barclay Thompson. Mrs Orgill was still working here but no longer controlled the prectice, having given it up to Barclay. Taylor served as medical officer for the Shire for before his death in 1939. After Taylor's death Dr. T. C. Reeves bought his practice in 1939, later that year being appointed medical officer,
Gladstone Road in Dandenong is named after her family, who owned and occupied a farming paddock in the area on former Police Paddock ground, the Police reserve having earlier been reduced back to Stud Road.
Hydropathy (now known as Hydrotherapy) and also called water cure, is a part of medicine and alternative medicine, in particular of naturopathy, occupational therapy and physiotherapy, that involves the use of water for pain relief and treatment.